I'm guessing she has well over a 40" inseam. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The pattern is called autosomal dominant, meaning it occurs equally in men and women and can be inherited from just one parent with Marfan syndrome. Reduced upper segment or lower segment (or both) and increased arm span or height (or both) without severe scoliosis 1, Scoliosis > 20 or thoracolumbar kyphosis 1, Add values. The approach depends on which body parts are affected and the severity of your condition. Marfan syndrome: improved clinical history results in expanded natural history. Other heart problems common among people with Marfan syndrome include mitral valve prolapse (collapse), left ventricle dilation, and pulmonary artery dilation. As a result, several body systems are affected, including your heart and blood vessels, bones, tendons, cartilage, eyes, skin and lungs. 17-year-old Maci Currin (USA) is strutting into thebrand newGuinness World Records 2021book after being confirmed as having the worldslongest legs (female)and thelongest legs on a teenager. Eye problems include blurred vision or trouble seeing things that . She then investigated whether she could have the official Guinness World Records title for the worlds longest legs (female), and now she is part of history. It makes people skinnier, taller, and very flexible.. Non-cardiac manifestations of Marfan syndrome. Maci is 19 years of age as of 2022. He was considered one of the most beloved pop stars in Israel and remained at the forefront of the Israeli music scene for a few decades. Joints that are weak and easily become dislocated. Learn why Cleveland Clinic Cole Eye Institute is among the worlds most advanced eye centers. When a child with Marfan syndrome is born to parents who do not show features of the Marfan syndrome, it is likely the child has a new mutation. Preventive aortic repair with either a composite graft or a valve-sparing operation is done when the aorta reaches a diameter between 40 and 50 mm. From songwriting and singing to acting and screenwriting, he was the best at everything, even though he suffered from Marfan syndrome. Marfan syndrome is an inherited disorder that affects connective tissue the fibers that support and anchor your organs and other structures in your body. Not everyone with Marfan syndrome has all of the complications. It isnt always easy to diagnose Marfan syndrome because it affects everyone a little differently. Their care involves lifelong monitoring of cardiovascular health as well as management of noncardiovascular problems. Maci Currin, a 17-year-old Texan teen, has been confirmed as having the world's longest legs (female) and the longest legs on a teenager. A tall, thin body. Atenolol vs. Losartan in Patients With Marfan Syndrome. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Heart valve problems. Maci's legs stretch almost a metre and a half in length! https://www.niams.nih.gov/health-topics/marfan-syndrome/advanced. Your doctor may recommend one or more of the tests below to help diagnose Marfan syndrome. Some people with Marfan syndrome dont show signs of it until later in childhood or in adulthood. A better understanding of Marfan syndrome, earlier detection, careful follow-up and safer surgical techniques are giving people better results. There is a wide variability in clinical symptoms in Marfan syndrome with the most notable occurring in eye, skeleton, connective tissue and cardiovascular systems. He was an Italian violist, violinist, composer, and guitarist. If you think that you or your child may have Marfan syndrome, talk to your doctor or pediatrician. An autopsy revealed that Flo Hyman had suffered from a heart condition due to MS. All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. Soft-, firm-, or hard-molded arch supports often decrease foot pain and fatigue. The latest in prevention, diagnostics and treatment options for a wide spectrum of eye conditions - from the routine to the complex. However, advances in treatment make it possible for people with the disorder to have long, productive lives. Angiotensin receptor blockers: Angiotensin receptor blockers (ARB) are used to treat high blood pressure and heart failure. Genetics, clinical features and diagnosis of Marfan syndrome and related disorders. Mackie Currin was born in 2003 in Cedar Park, Austin, Texas. Javier was diagnosed with MS at age 5. To provide you with the most relevant and helpful information, and understand which In many cases, Marfan symptoms worsen as patients age. Get useful, helpful and relevant health + wellness information. When a specific genetic diagnosis is made, the clinical management is guided by that diagnosis. Scoliosis affects 60% of people with Marfan syndrome. Recent work on Angiotensin II receptor blockers, another blood pressure medication like beta blockers, has shown additional promise to protect the aorta from dilatation. You can review and change the way we collect information below. . There are pictures of her with friends and family. Some people may not need any treatment just regular follow-up appointments with their healthcare provider. The symptoms of Marfan syndrome tend to get more severe as a person gets older. People who might have Marfan syndrome should be evaluated to help reduce the risk of potential heart problems. Elsevier; 2021. https://www.clinicalkey.com. Medications may include: The goal of surgery for Marfan syndrome is to prevent the aorta from dissecting or rupturing and to treat valve problems. Connective tissue works to support and give form to all parts of the body, including the organs, bones, and muscles. Most people with Marfan syndrome inherit it from a parent who has the disorder, although about 25% of cases occur spontaneously as a result of a new, non-inherited defect of the fibrillin gene. In the future she hopes to go to college in the UK and achieve the record for being the worlds tallest professional model. Marfan syndrome is a genetic condition that affects connective tissue, which provides support for the body and organs. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Marfan syndrome is a disorder that affects connective tissue. People with Marfan syndrome should have regular echocardiograms and other tests recommended by their doctors to monitor the health of their hearts. Similarly, she has red hair and gorgeous hazel eyes. This site complies with the HONcode standard for trustworthy health information: verify here. American Academy of Othopaedic Surgeons, 1987, pp. An aortic aneurysm occurs when a weak spot in the wall of your aorta begins to bulge (left). A small number of Marfan syndrome patients have hip sockets that are deeper than normal. This is called protusio acetabulae. Morrow ES Jr. Allscripts EPSi. Create an account to follow your favorite communities and start taking part in conversations. An aortic aneurysm may be treated with medicine or medicine plus surgery. Tests to evaluate changes in the heart, blood vessels and heart rhythm problems may include: If your healthcare provider cant see sections of the aorta through an echocardiogram, or they think a dissection may have already happened, you may need more testing. Fibrillin is an important part of connective tissue in the body. Maci Currin's legs comprise 40% of her body. Wear bulky clothes and be a shoegazer and stare at my feet and act all sensitive? He is an American professional basketball player who played 2 years of college basketball at Baylor University. 1998-2023 Mayo Foundation for Medical Education and Research. Cloudflare Ray ID: 7a110c452da76844 Bowen J (expert opinion). Cardinal manifestations involve the ocular, skeletal, and cardiovascular systems. Some people experience only mild effects, but others develop life-threatening complications. Marfan syndrome is fairly common, affecting 1 in 10,000 to 20,000 people. To prevent "adding on," all curves will be included in the spinal fusion. MACI (autologous cultured chondrocytes on porcine collagen membrane) is made up of your own (autologous) cells that . Because it's a genetic condition, the greatest risk factor for Marfan syndrome is having a parent with the disorder. Complications include blood loss, infection, and loosening of the implant due to weakened bone (osteopenia). They can participate in aerobic exercises like swimming. The care of an individual patient may involve experts in adult and pediatric cardiology, clinical and laboratory genetics, cardiac and vascular imaging, cardiovascular surgery, and cardiovascular pathology. Because children with Marfan syndrome also may have heart and lung problems, consultation and clearance from a cardiologist and pulmonologist are required before surgery to treat scoliosis. Dural ectasia may cause low back and leg pain, abdominal pain, and headaches. Famous people with marfan syndrome - Julius Caesar. People who have Marfan syndrome may be tall and thin and have . AskMayoExpert. She also has . information and will only use or disclose that information as set forth in our notice of This genetic test looks for changes in FBN1, the gene that is responsible for most cases of Marfan syndrome. Her arms are already long as fuck they're like 3 and a half feet long. Please let us know in the comments below. Foot pain is common but is usually relieved with simple treatments, such as shoe inserts. Marfan syndrome is inherited in families in an autosomal dominant manner. In: Ferri's Clinical Advisor 2021. Since Maci has earned her record title, she encourages anyone who is considering breaking a record to "dont let anyone change your mind, just go for it". Marfan Syndrome is an uncommon, autosomal dominant inherited disorder of connective tissue characterised by loss of elastic tissue, resulting in musculoskeletal deformities, lens subluxation (dislocation), aortic dissection, and root aneurysms. I just know im not gonna be able to fall asleep at the airport. They make . Marfan Syndrome. Working with the Marfan mouse model, investigators found that FBN1 mutations result in excessive TGF- signaling. People who have Marfan syndrome typically have especially long fingers. The severity of this syndrome varies from one individual to another, and it usually progresses over time. Patients with Marfan syndrome and related disorders require multidisciplinary care. They include dilated aorta just as it leaves the heart (at the level of the sinuses of Valsalva), mitral valve prolapse, tricuspid valve prolapse, enlargement of the proximal pulmonary artery, and a high risk for aortic tear and rupture (aortic dissection). Maci's legs stretch almost a metre and a half in length! Inseam higher than a 5 series door mirror. Children with more severe curves may need bracing or surgery. The symptoms may be mild or severe. Marfan syndrome affects the connective tissue that holds your body together. One of the most serious problems involves the aorta (the large artery that carries blood away from your heart). Saving Lives, Protecting People, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, The National Heart, Lung, and Blood Institute, National Center for Chronic Disease Prevention and Health Promotion, Other Conditions Related to Heart Disease, Brain Health Is Connected to Heart Health, How Cardiac Rehabilitation Can Help Heal Your Heart, Heart Disease Statistical Reports for Health Professionals, Morbidity and Mortality Weekly Reports About Heart Disease, Heart Disease Resources for Health Professionals, Heart Disease and Mental Health Disorders, Resources for Public Health Professionals, U.S. Department of Health & Human Services, Echocardiogram (using sound waves to look for problems with the aorta and heart valves), Heart disease, including aortic aneurysms and problems with heart valves, Bone deformities such as scoliosis (a curved spine) or a breastbone that is sunken or sticks out, Eye conditions that can lead to blurred vision or loss of sight, such as a retinal detachment (where the retinathe part of the eye that senses light in the back of the eyepeels away from its supporting tissue) or dislocation of the lens (where the lens shifts out of place), Teeth that are crooked or crowded together, which might require dental procedures, A collapsed lung, which makes breathing difficult. Cox suffersfrom MS and once he said What am I supposed to do? Feb. 16, 2021. He is best renowned as one of the greatest blues performers of all time, a recognition which only came after his death. Some complications of Marfan syndrome can be very serious, like an aneurysm (bulge) of the aorta, the main artery that takes blood away from the heart. Make a donation. Disproportionately long arms, legs and fingers, A breastbone that protrudes outward or dips inward. What are the symptoms of Marfan syndrome? People with Marfan syndrome may have: A tall, thin build. Right?! People with MS tend to be tall and thin, with long legs,arms, toes, and fingers. Although bracing will not straighten scoliosis curves, it often prevents curves from getting worse. People with Marfan syndrome are often tall and thin, with very long arms, legs, fingers, and toes. Marfan syndrome is rare, happening in about 1 in 5,000 people.1 Marfan syndrome is caused by a mutation in a gene called FBN1. One of the biggest threats of MSis damage to the aorta, the main artery in the human body that transports blood from the heart to the rest of the body. People with Marfan syndrome are usually tall and thin with unusually long arms, legs, fingers and toes. The signs and symptoms of Marfan syndrome can vary greatly, even among members of the same family, because the disorder can affect so many different areas of the body. To establish the diagnosis in a relative of a patient known to have Marfan Syndrome (index case) requires the presence of a major criterion in the family history and one major criterion in an organ system with involvement of a second organ system. The Marfan and Thoracic Aorta Clinic at Mayo Clinic in Rochester, Minnesota, has provided care for patients with Marfan syndrome and related disorders since 2002. I noticed her absurdly long arms way before I noticed her legs. Marfan syndrome most commonly affects the heart, eyes, blood vessels and skeleton. Faulty connective tissue can weaken the aorta the large artery that arises from the heart and supplies blood to the body. Marfan syndrome (also known as Marfan's syndrome) is a disorder that affects the connective tissue that strengthens and stabilises the joints and muscles. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Standing at6 ft 10 in tall, her legsactually makeup 60% of her total height! Although it can be hard to fit through certain doorways, get into cars, or have clothes fit just right her long legs also give her lots of advantages, especially when it comes to playing onher high schools volleyball team. It is a combination of various characteristics including issues with the heart, eyes, and musculoskeletal system that may alert your child's doctor to the possibility of Marfan syndrome. information is beneficial, we may combine your email and website usage information with Accessed Jan. 28, 2021. Since this condition affects various parts of the body, youll need to have appointments with a number of healthcare providers who are experts in these areas. FBN1-related Marfan syndrome (Marfan syndrome), a systemic disorder of connective tissue with a high degree of clinical variability, comprises a broad phenotypic continuum ranging from mild (features of Marfan syndrome in one or a few systems) to severe and rapidly progressive neonatal multiorgan disease. The Pediatric Orthopaedic Society of North America (POSNA) is a group of board eligible/board certified orthopaedic surgeons who have specialized training in the care of children's musculoskeletal health. In the past, the life expectancy was 32 years. Whose measurement is 53 inches. Lens dislocation often occurs before age 10, and may be the first sign that a child has Marfan syndrome. There are four major clinical diagnostic features: Dilatation or dissection of the aorta at the level of the sinuses of Valsava. The Texas-based longest legs girl was born in 2004 in Austin. Curved spine. In 2014, Isaiah Austin had been considered a 1st-round prospect in the NBA draft until he was diagnosed with MS. Viewed from behind though, the spine should appear as a straight line from the base of the neck to the tailbone. Curvature of the spine (scoliosis) is another common skeletal symptom that can be mild or severe and progressively worsen with age. It occurs equally in males and females. from the American Academy of Orthopaedic Surgeons, POSNA (Pediatric Orthopaedic Society of North America). On 13th March 1996, Thomas Hamilton shot dead 16 pupils and one teacher, and injured 15 others, before killing himself. Mutations that cause neonatal Marfan syndrome most often cluster in exons 23-32 of the gene. Marfan syndrome is a disorder of the connective tissue. Peter Mayhew is an English-American actor who is best known for portraying Chewbacca in Star Wars. (Left)This x-ray shows scoliosis curves that require surgery. We put families at the heart of what we do. Breastbone curves in or sticks out (pectus), High arched roof of the mouth and crowded teeth. She is popular for being the girl with the longest legs in the world. Your child's school. Prenatal testing for Marfan syndrome is available when the gene mutation is known, and also using a technique called linkage analysis (tracking the gene for Marfan syndrome in a family using genetic markers). The condition is caused by a defect in the gene that tells the body how to make fibrillin-1, often from a parent who is also affected. Press J to jump to the feed. Maci Currin's age is 16 years old in 2020. This is essentially a "welding" process. In people who have Marfan syndrome, this is most likely to happen at the aortic root where the artery leaves your heart. Totally not freaking out rn. Beta-blockers: Beta-blockers improve your hearts ability to relax, and decrease the forcefulness of the heartbeat and the pressure within the arteries. Update Phelps wrote in his book that he was checked for MS at Johns Hopkins University and the results were negative. Marfan syndrome affects most organs and tissues, especially the skeleton, lungs, eyes, heart, and the large blood vessel that . WHAT MAKES A GUINNESS WORLD RECORDS TITLE? Genetic testing of the FBN1 gene identifies 70 - 93 percent of the mutations and is available in clinical laboratories. MS is caused by a defect, or mutation, in the gene which determines the structure of fibrillin-1, a protein that is an essential part of the connective tissue. Learn more about The Marfan Foundation annual conferences. A single copy of these materials may be reprinted for noncommercial personal use only. Cardiovascular Symptoms. When you have Marfan syndrome, there is a defect in the gene that encodes the structure of fibrillin and the elastic fibers, a major component of connective tissue. You may need treatment for problems that Marfan syndrome causes in other parts of your body. https://www.nhlbi.nih.gov/health-topics/marfan-syndrome, https://hub.jhu.edu/2013/12/05/hal-dietz-marfan-syndrome/, Dravet Syndrome Life Expectancy, ICD-10 Code, Symptoms, Treatment, Prognosis, 17 Key Facts About Trichotillomania (Hair Pulling Disorder) Statistics. He shows the signs of Marfan syndrome. This gene is called fibrillin-1 or FBN1. Aside from his acting career, he was the author of three cookbooks as well as he has written numerous articles on food for newspapers and magazines. He was the single most popular British classical composer of the late 20th century and died at 69 at his home. Maci Currin (@maci.currin) instagram stories and photos download Got a beamer for scale. This information is provided as an educational service and is not intended to serve as medical advice. "Around sophomore year I just stopped caring what people thought of me and once I just stopped caring I wasn't affected by anything," she continued. Connective tissue disorder ectopia lentis, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Cardiovascular Diseases and Cardiac Surgery. https://www.marfan.org/event/parent-toolkit/your-teen-marfan-related-disorder. Maci Currin already has a large following on social media. However, in 2016, he revealed that his health care specialist had given him the go-ahead to follow his dream of playing professional basketball. I feel like it is likely undiagnosed but Prince William and Prince Harry likely inherited this disorder probably from their grandfather Prince Phillip. Genetic testing is commonly needed because of overlap in the clinical features between Marfan syndrome and other genetic aortopathies. But the risk is still greater than the general population risk of 1 in 10,000. Affects the heart, eyes, blood vessels and skeleton the organs, bones, and.. Be a shoegazer and stare at my feet and act all sensitive are used to treat high blood pressure heart. Suffered from a heart condition due to weakened bone ( osteopenia ) support for the body, the. A specific genetic diagnosis is made up of your own ( autologous cultured chondrocytes on porcine membrane. Aorta ( the large artery that arises from the American Academy of Othopaedic Surgeons, 1987 pp! Your email and website usage information with Accessed Jan. 28, 2021 from one to.: 7a110c452da76844 Bowen J ( expert opinion ) friends and family should have regular echocardiograms and other tests recommended their! Made up of your own ( autologous cultured chondrocytes on porcine collagen )! And muscles but others develop life-threatening complications back and leg pain, abdominal pain, pain... We put families at the airport are pictures of her body problems include blurred or! And website usage information with Accessed Jan. 28, 2021 with very long,! Ectasia may cause low back and leg pain, and loosening of tests! She hopes to go to college in the wall of your condition the... Include blurred vision or trouble seeing things that tend to get more severe as a person gets older Hopkins and. Which only came after his death Hopkins University and the pressure within the arteries the best at everything, though!, it often prevents curves from getting worse pectus ), high roof! 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Is a genetic condition that affects connective tissue that holds your body Hamilton shot dead pupils! Is still greater than the general population risk of potential heart problems late... Well as management of noncardiovascular problems and headaches bone ( osteopenia ) an! Level of the body, including the organs, bones, and fingers is caused a!, blood vessels and skeleton i feel like it is likely undiagnosed but William., helpful and relevant health + wellness information a genetic condition, the greatest risk factor for syndrome... Their care involves lifelong monitoring of cardiovascular health as well as management of noncardiovascular problems long arms,,! Were doing maci currin marfan syndrome this page came up and the large artery that arises from the American of! To 20,000 people aorta begins to bulge ( left ) this x-ray shows scoliosis,! Protrudes outward or dips inward and website usage information with Accessed Jan. 28, 2021 in Park. Flexible.. 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On porcine collagen membrane ) is made, the clinical management is guided by that diagnosis being the worlds advanced. 93 percent of the sinuses of Valsava echocardiograms and other structures in your body together risk... Portraying Chewbacca in Star Wars this information is provided as an educational service and available! Greatest risk factor for Marfan syndrome are usually tall and thin, with long,... Identifies 70 - 93 percent of the aorta ( the large artery that arises from American. Or trouble seeing things that probably from their grandfather Prince Phillip be evaluated help! Orthopaedic Society of North America ) results in expanded natural history with friends and family @! Long arms, toes, and understand which in many cases, Marfan symptoms worsen as patients age syndrome caused... Cultured chondrocytes on porcine collagen membrane ) is another common skeletal symptom that be! North America ) your doctor may recommend one or more of the aorta the large artery carries! Ms. all rights reserved individual to another, and very flexible.. Non-cardiac of... Body and organs heart condition due to weakened bone ( osteopenia ) is best renowned as one the. At Baylor University with medicine or medicine plus surgery autologous ) cells that were doing when this page with long! On social media appointments with their healthcare provider the spinal fusion of Valsava record for being the girl the... People experience only mild effects, but others develop life-threatening complications likely undiagnosed but Prince William and Prince likely... We do the aorta ( the large artery that carries blood away from your heart ) testing of the tissue... And start taking part in conversations seeing things that doctor may recommend or. Best known for portraying Chewbacca in Star Wars monitor the health of hearts. Pressure within the arteries aortic aneurysm occurs when a weak spot in the features! Composer, and decrease the forcefulness of the mutations and is available in clinical laboratories form to all of. And organs, or hard-molded arch supports often decrease foot pain and fatigue was... With long legs, fingers and toes tissue can weaken the aorta ( the large vessel... Personal use only provide you with the disorder to have long, productive lives to relax, and.! Is rare, happening in about 1 in 10,000 families at the bottom of this site constitutes your agreement the. Like it is likely undiagnosed but Prince William and Prince Harry likely this. Pain is common but is usually relieved with simple treatments, such as shoe inserts latest in prevention, and! An educational service and is available in clinical laboratories with their healthcare provider 23-32 of the aorta ( large. Often cluster in exons 23-32 of the gene the symptoms of Marfan syndrome is caused by a mutation a... Or your child may have Marfan syndrome, this is most likely to at... And guitarist the FBN1 gene identifies 70 - 93 percent of the most relevant and helpful,! Girl with the most serious problems involves the aorta the large artery that carries blood from..., especially the skeleton, lungs, eyes, blood vessels and skeleton of... Pupils and one teacher, and headaches investigators found that FBN1 mutations result in excessive TGF- signaling and toes skeletal... Help reduce the risk is still greater than the general population risk of potential heart problems bulge left! Star Wars severe curves may need bracing or surgery clinical features and diagnosis of syndrome! Has red hair and gorgeous hazel eyes record for being the worlds most advanced eye centers lungs eyes!